Accumulation and Net Change in Context

When a rate of change is known, the integral of the rate tells how much the quantity changes. Most applied questions about integrals come down to this one fact, read with the right units.
The units of the integral are the units of the rate times the units of the variable. A rate in liters per minute, integrated over minutes, gives liters. An interpretation names the quantity, its units, and the interval.

Rates in and rates out

When a quantity gains at a rate I(t)I(t) and loses at a rate O(t)O(t), its rate of change is I(t)−O(t)I(t) - O(t). The amount is
A(t)=A(a)+∫at(I(s)−O(s)) ds.A(t) = A(a) + \int_{a}^{t} \big(I(s) - O(s)\big)\,ds.
When II and OO are continuous, A′(t)=I(t)−O(t)A'(t) = I(t) - O(t) by the Fundamental Theorem. The largest and smallest amounts on a closed interval occur at an end or where I−OI - O changes sign.

Rates with respect to distance

The variable doesn't have to be time. A rate per meter, per kilometer, or per unit of any input integrates the same way. The integral's units are the rate's units times the input's units.